« Back
Home /
bay1217389

bay1217389

Item no.	V4195-500mg
Manufacturer	InvivoChem LLC
CASRN	1554458-53-5
Amount	500mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4195CAS #:1554458-53-5Purity >=98% Description: BAY 1217389 is a novel, potent, orally bioavailable and selective inhibitor of the serine/threonine kinase monopolar spindle 1 (MPS1) with an IC50 value less than 10 nM. BAY1217389 has potential antineoplastic activity. BAY 1217389 selectively binds to and inhibits the activity of Mps1. This inactivates the spindle assembly checkpoint (SAC), accelerates mitosis, causes chromosomal misalignment and missegregation, and mitotic checkpoint complex destabilization. This induces cell death in Mps1-overexpressing cancer cells. Description: References: Mol Cancer Ther. 2016 Apr; 15(4):583-92. References:
	Name: BAY1217389 CAS#: 1554458-53-5 Chemical Formula: C27H24F5N5O3 Exact Mass: 561.1799 Molecular Weight: 561.513 Elemental Analysis: C, 57.75; H, 4.31; F, 16.92; N, 12.47; O, 8.55
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: BAY1217389; BAY-1217389; BAY 1217389. IUPAC/Chemical Name: N-cyclopropyl-4-(6-(2, 3-difluoro-4-methoxyphenoxy)-8-((3, 3, 3-trifluoropropyl)amino)imidazo[1, 2-b]pyridazin-3-yl)-2-methylbenzamide InChi Key: WNEILUNVMHVMPH-UHFFFAOYSA-N InChi Code: InChI=1S/C27H24F5N5O3/c1-14-11-15(3-6-17(14)26(38)35-16-4-5-16)19-13-34-25-18(33-10-9-27(30, 31)32)12-22(36-37(19)25)40-21-8-7-20(39-2)23(28)24(21)29/h3, 6-8, 11-13, 16, 33H, 4-5, 9-10H2, 1-2H3, (H, 35, 38) SMILES Code: O=C(NC1CC1)C2=CC=C(C3=CN=C4C(NCCC(F)(F)F)=CC(OC5=CC=C(OC)C(F)=C5F)=NN43)C=C2C

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 500mg

available

Delivery expected until 10/4/2024

Express Delivery: Save 11 days

Compare

Add to wishlist

Recommend by mail