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bay-65-1942-r-isomer

bay-65-1942-r-isomer

Item no.	V4191-25mg
Manufacturer	InvivoChem LLC
CASRN	758683-21-5
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4191CAS #:758683-21-5 Purity >=98% Description: Bay 65-1942 R-isomer is the R-enantiomeric isomer of BAY65-1942 which is a novel, potent and selective ATP-competitive inhibitor of IKKbeta. It selectively targets IKKbeta kinase activity. IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury. Animals pretreated with Bay 65-1942 (n=3) have significantly attenuated CK-MB levels compared with those animals without treatment prior to IR (14, 170 +/-3, 219 units, P< 0.05 vs. vehicle) Description: References: Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2248-53.; PLoS One. 2013 Jun 24; 8(6):e66755. References: Related CAS#: 600734-02-9 (free base); 600734-06-3 (HCl salt)
	Name: BAY65-1942 R-isomer CAS#: 758683-21-5 (BAY65-1942 R-isomer) Chemical Formula: C22H25N3O4 Exact Mass: 395.1845 Molecular Weight: 395.459 Elemental Analysis: C, 66.82; H, 6.37; N, 10.63; O, 16.18
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: BAY 65-1942 R-isomer; BAY-65-1942; BAY65-1942; BAY 651942; BAY-651942; BAY651942 IUPAC/Chemical Name: (R)-7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(piperidin-3-yl)-1, 4-dihydro-2H-pyrido[2, 3-d][1, 3]oxazin-2-one InChi Key: IGJVFGZEWDGDOO-CQSZACIVSA-N InChi Code: InChI=1S/C22H25N3O4/c26-18-4-1-5-19(28-11-13-6-7-13)20(18)17-9-15(14-3-2-8-23-10-14)16-12-29-22(27)25-21(16)24-17/h1, 4-5, 9, 13-14, 23, 26H, 2-3, 6-8, 10-12H2, (H, 24, 25, 27)/t14-/m1/s1 SMILES Code: OC(C=CC=C1OCC2CC2)=C1C3=NC4=C(COC(N4)=O)C([CH]5CNCCC5)=C3

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Amount: 25mg

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Delivery expected until 10/4/2024

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