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pf-429242-dihydrochloride

pf-429242-dihydrochloride

Item no.	V4145-25mg
Manufacturer	InvivoChem LLC
CASRN	2248666-66-0
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4145CAS #:2248666-66-0 Purity >=98% Description: PF429242 dihydrochloride is a novel, potent, reversible and competitive S1P sterol regulatory element-binding protein (SREBP) site 1 protease inhibitor with an IC50 of 170 nM. PF 429242 showed no significant inhibition of trypsin, elastase, proteinase K, plasmin, kallikren, factor XIa, thrombin, or furin at concentrations up to 100 uM and only modest inhibition of urokinase (IC50 = 50 uM) and factor Xa (IC50 = 100 uM). PF-429242 is selective for site 1 protease against a panel of serine proteases. PF-429242 inhibits rate of cholesterol synthesis in CHO cells with IC50 of 0.53 uM. Description: References: J Pharmacol Exp Ther. 2008 Sep; 326(3):801-8.; Viruses. 2016 Feb 10; 8(2). pii: E46.; J Virol. 2011 Jan; 85(2):795-803. References: Related CAS#:947303-87-9 (free base)

Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: PF-429242 2HCl; PF 429242; PF429242 dihydrochloride IUPAC/Chemical Name: (R)-4-((diethylamino)methyl)-N-(2-methoxyphenethyl)-N-(pyrrolidin-3-yl)benzamide dihydrochloride

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25mg

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Delivery expected until 9/6/2024

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