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Description: Fabesetron (FK1052) is a novel, potent and orally bioactive 5-HT3 receptor antagonist with 5-HT4 receptor antagonistic activity. It has the potential to be used in treating acute and delayed emesis induced by cancer chemotherapy.
References:
1. Effect of FK1052, a potent 5-hydroxytryptamine3 and5-hydroxytryptamine4 receptor dual antagonist, on colonic function invivo. J Pharmacol Exp Ther. 1993 Jul; 266(1):74-80.
2. Antiemetic activity of FK1052, a 5-HT3- and5-HT4-receptor antagonist, in Suncus murinus and ferrets. J PharmacolSci. 2005 Aug; 98(4):396-403.
Related CAS No. : 129299-81-6 ((+/-)-FK1052 HCl)
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