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abi-274

abi-274

Item no.	V41098-10mg
Manufacturer	InvivoChem LLC
CASRN	1253697-93-6
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V41098CAS #:1253697-93-6Purity >=98% Description: ABI-274 is a novel, orally bioavailable, highly potent and selective tubulin/mitotic inhibitor (specifically a microtubule destabilizer) targeting the colchicine binding site, belonging to the so called colchicine binding site inhibitor (CBSI). It has shown potent anticancer activities in vitro and in vivo, as well as favorable pharkacokinetics such as good oral bioavailability. References: 1. Chen J, Wang Z, Li CM, Lu Y, Vaddady PK, Meibohm B, Dalton JT, Miller DD, Li W. Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents. J Med Chem . 2010 Oct 28; 53(20):7414-27. doi: 10.1021/jm100884b. 2. Wang J, Chen J, Miller DD, Li W. Synergistic combination of novel tubulin inhibitor ABI-274 and vemurafenib overcome vemurafenib acquired resistance in BRAFV600E melanoma. Mol Cancer Ther. 2014 Jan; 13(1):16-26. doi: 10.1158/1535-7163.MCT-13-0212. 3. Wang Z, Chen J, Wang J, Ahn S, Li CM, Lu Y, Loveless VS, Dalton JT, Miller DD, Li W. Novel tubulin polymerization inhibitors overcome multidrug resistance and reduce melanoma lung metastasis. Pharm Res. 2012 Nov; 29(11):3040-52. doi: 10.1007/s11095-012-0726-4. Epub 2012 Mar 13. PMID: 22410804 4. Li CM, Chen J, Lu Y, Narayanan R, Parke DN, Li W, Ahn S, Miller DD, Dalton JT. Pharmacokinetic optimization of 4-substituted methoxybenzoyl-aryl-thiazole and 2-aryl-4-benzoyl-imidazole for improving oral bioavailability. Drug Metab Dispos. 2011 Oct; 39(10):1833-9. doi: 10.1124/dmd.110.036616. Epub 2011 Jul 8. PMID: 21742898

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Amount: 10mg

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