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incb053914-phosphate

incb053914-phosphate

Item no.	V4088-25mg
Manufacturer	InvivoChem LLC
CASRN	2088852-47-3
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4088CAS #:2088852-47-3Purity >=98% Description: INCB053914 is a novel, potent, selective, and ATP-competitive small molecule pan-inhibitor of PIM (Proviral Integration site of Moloney murine leukemia virus) kinases with IC50 values of 0.24 nM, 30 nM and 0.12 nM for PIM1, PIM2 and PIM3 respectively in biochemical assays. In cell proliferation assays, INCB053914 is active as a single agent in the majority of cell lines derived from different hematological malignancies, including MM, AML, DLBCL, MCL and T-ALL, with IC50values ranging from 3 - 300 nM. INCB053914 synergizes with a variety of cytotoxic and targeted agents, reducing the viability of a panel of hematological tumor cell lines. In pharmacodynamic assays, INCB053914 inhibits phosphorylation of S6RP, P70S6K, 4E-BP-1 and BAD, known PIM kinase targets. INCB053914 may have therapeutic utility in hematologic malignancies when combined with other inhibitors of oncogenic kinases or standard chemotherapeutics. Description: References: PLoS One. 2018 Jun 21; 13(6):e0199108; http://cancerres.aacrjournals.org/content/75/15_Supplement/5397 References: Related CAS#:1620012-39-6 (free base)
Molecular Weight (MW)	611.51
Formula	C26H26F3N5O3.H3O4P
CAS No.	2088852-47-3 (phosphate salt);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 50 mg/mL
	Water: N/A
	Ethanol: N/A
Chemical Name	N-((R)-4-((3R, 4R, 5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)-7-hydroxy-6, 7-dihydro-5H-cyclopenta[b]pyridin-3-yl)-6-(2, 6-difluorophenyl)-5-fluoropicolinamide phosphoric acid
Synonyms	INCB53914 phosphate; INCB-53914; INCB 53914; INCB053914; INCB-053914; INCB 053914 phosphate
SMILES Code	O=C(C1=NC(C2=C(F)C=CC=C2F)=C(F)C=C1)NC3=CN=C4C(CC[CH]4O)=C3N5C[CH](N)[CH](O)[CH](C)C5.OP(O)(O)=O

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Amount: 25mg

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