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gsk-5959

gsk-5959

Item no.	V4084-500mg
Manufacturer	InvivoChem LLC
CASRN	901245-65-6
Amount	500mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4084CAS #:901245-65-6 Purity >=98% Description: GSK5959 is a novel, potent, selective and cell permeable BRPF1 (bromodomain and PHD finger-containing) bromodomain inhibitor with an IC50 of 80 nM. It exhibits > 100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. The BRPF protein family are important scaffolding proteins for assembly of MYST histone acetyltransferase complexes and are involved in the epigenetic regulation of gene expression and have been implicated in human cancer. Description: References: ACS Med Chem Lett. 2014 Sep 10; 5(11):1190-5. References:
Molecular Weight (MW)	394.48
Formula	C22H26N4O3
CAS No.	901245-65-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 10 mg/mL
	Water: N/A
	Ethanol: N/A
Chemical Name	N-[2, 3-Dihydro-1, 3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide
Synonyms	GSK-5959; GSK 5959; GSK5959
SMILES Code	O=C(NC1=C(N2CCCCC2)C=C(N3C)C(N(C)C3=O)=C1)C4=CC=CC=C4OC

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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