« Back
Home /
motesanib

motesanib

Item no.	V4082-10mg
Manufacturer	InvivoChem LLC
CASRN	453562-69-1 (free base)
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4082CAS #:453562-69-1 (free base)Purity >=98% Description: Motesanib (formerly also known as AMG-706) is a novel, potent, ATP-competitive, orally bioavailable inhibitor of VEGFR1/2/3 (vascularendothelial growth factor) with IC50 of 2 nM/3 nM/6 nM, respectively; ithas potential anticancer activity; Motesanib shows similar activityagainst Kit, and ca.10-fold more selective for VEGFR than PDGFR and Ret.Motesanib selectively targets and inhibits VEGFR, PDGFR, kit, and Retreceptors, thereby inhibiting angiogenesis and cellular proliferation. Description: References: Cancer Res. 2006; 66(17):8715-21; Clin Cancer Res. 2010; 16(14):3639-47; Clin Cancer Res. 2009; 15(1):110-8. References: Related CAS: 453562-69-1 (free base); 57876-30-3 (phosphate)
Molecular Weight (MW)	373.46
Formula	C22H23N5O
CAS No.	453562-69-1 (free base); 857876-30-3 (diphosphate)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 30 mg/mL
	Water: N/A
	Ethanol: N/A
SMILES	O=C(C1=CC=CN=C1NCC2=CC=NC=C2)NC3=CC4=C(C=C3)C(C)(C)CN4
Synonyms	AMG-706; AMG 706; AMG706 Chemical Name: N-(3, 3-dimethyl-2, 3-dihydro-1H-indol-6-yl)-2-[(pyridin-4- ylmethyl)amino]pyridine-3-carboxamide InChi Key: RAHBGWKEPAQNFF-UHFFFAOYSA-N InChi Code: InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12, 26H, 13-14H2, 1-2H3, (H, 24, 25)(H, 27, 28) SMILES Code: O=C(C1=CC=CN=C1NCC2=CC=NC=C2)NC3=CC4=C(C=C3)C(C)(C)CN4

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 10mg

available

Delivery expected until 10/4/2024

Express Delivery: Save 9 days

Compare

Add to wishlist

Recommend by mail