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tandutinib-hcl

tandutinib-hcl

Item no.	V40669-50mg
Manufacturer	InvivoChem LLC
CASRN	387867-13-2 (free base)?
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V40669CAS #:387867-13-2 (free base)?Purity >=98% Description: Tandutinib HCl (MLN-518, CT-53518) is a novel, potent and selective FLT3 antagonist with IC50 of 0.22 uM, it also inhibits PDGFR and c-Kit, 15 to 20-fold higher potency for FLT3 versus CSF-1R and > 100-fold selectivity for the same target versus FGFR, EGFR and KDR. Tandutinib has potential antineoplastic activity. Tandutinib inhibits the autophosphorylation of FLT3 (FMS-Like Tyrosine kinase-3), c-KIT and PDGF (platelet-derived growth factor) receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis. Description: References: Cancer Cell. 2002 Jun; 1(5):421-32; Blood. 2004 Nov 1; 104(9):2912-8. References: Relaced CAS: 387867-13-2 (free base)

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Amount: 50mg

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Delivery expected until 9/6/2024