« Back
Home /
protein-degrader-1-hydrochloride

protein-degrader-1-hydrochloride

Item no.	V4063-100mg
Manufacturer	InvivoChem LLC
CASRN	1448189-80-7
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4063CAS #:1448189-80-7 Purity >=98% Description: Protein degrader 1 HCl (hydrochloride) is a novel and potent small molecule ligand for VHL (Von Hippel-Lindau), an E3 ligase which has been targeted in many PROTACs (proteolysis-targeting chimeras). Small molecule-induced protein degradation is an attractive strategy for the development of chemical probes. One method for inducing targeted protein degradation involves the use of PROTACs, heterobifunctional molecules that can recruit specific E3 ligases to a desired protein of interest. PROTACs have been successfully used to degrade numerous proteins in cells, but the peptidic E3 ligase ligands used in previous PROTACs have hindered their development into more mature chemical probes or therapeutics. Description: References: ACS Chem Biol. 2015 Aug 21; 10(8):1831-7. References: Related CAS#: 1448297-52-6 (free base); 1631137-51-3 (TFA salt)
Molecular Weight (MW)	467.02
Formula	C??H??ClN?O?S
CAS No.	1448189-80-7 (HCl salt)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 10 mM
	Water: > 50 mg/mL
	Ethanol: N/A
Chemical Name	(2S, 4R)-1-((S)-2-amino-3, 3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Synonyms	Protein degrader 1 hydrochloride; Protein degrader 1 TFA; VH032-NH2 TFA; VHL ligand 1 TFA; Protein degrader 1 TFA , VHL-7526 TFA; VHL-7526; VHL7526; VHL 7526
SMILES Code	O=C([CH](C[CH](O)C1)N1C([CH](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 100mg

available

Delivery expected until 9/6/2024

Express Delivery: Save 9 days

Compare

Add to wishlist

Recommend by mail