ml311

Item no.	V4013-250mg
Manufacturer	InvivoChem LLC
CASRN	315698-17-0
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4013CAS #:315698-17-0 Purity >=98% Description: ML311 (also known as EU-5346) is a novel small molecule that potently and selectively disrupts the Mcl-1 and Bim protein-protein interaction and can be used as a chemical probe for studying Lymphoid Tumorigenesis. Mcl-1 is highly expressed in hematopoietic stem cells and is regulated by growth factors. Blocking the effects of Mcl-1, particularly through the inhibition of its interactions with pro-apoptotic oncogenes of the Bcl-2 family, is a promising approach for dramatically slowing tumor initiation, progression, and apoptosis resistance, especially in MM, where Mcl-1 is essential for tumor survival. Description: References: Biotechnology Information (US); 2010-2012 Apr 16. References:
Molecular Weight (MW)	415.46
Formula	C23H24F3N3O
CAS No.	315698-17-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 60mg/mL
	Water: N/A
	Ethanol: N/A
Chemical Name	7-[(4-Ethylpiperazin-1-yl)-[4-(trifluoromethyl)phenyl]methyl]quinolin-8-ol
Synonyms	EU-5346; EU 5346; EU5346; ML311; ML-311; ML 311
SMILES Code	OC1=C2N=CC=CC2=CC=C1C(N3CCN(CC)CC3)C4=CC=C(C(F)(F)F)C=C4

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