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Description: Gallopamil HCl (Methoxyverapamil HCl), a methoxy analog of Verapamil, is a a coronary vasodilator and a phenylalkylamine calcium antagonist. Gallopamil HCl inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 uM. Gallopamil HCl is a highly potent antiarrhythmic and vasodilator agent.
References:
1. BrogdenRN, et al. Gallopamil. A review of its pharmacodynamic andpharmacokinetic properties, and therapeutic potential in ischaemic heartdisease. Drugs. 1994 Jan; 47(1):93-115.
2. SewingKF, et al. Calcium channel antagonists verapamil and gallopamil arepowerful inhibitors of acid secretion in isolated and enriched guineapig parietal cells. Pharmacology. 1983; 27(1):9-14.
3. KirchengastM, et al. Reperfusion arrhythmias in closed-chest rats: the effect ofmyocardial noradrenaline depletion and Ca2(+)-antagonism. Clin ExpPharmacol Physiol. 1991 Apr; 18(4):217-21.
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