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Description: DIM-C-pPhOH (also known as C-DIM8) is a Nur77 (NR4A1) antagonist. DIM-C-pPhOH inhibits lung cancer cell and tumor growth in a metastasis model. Treatment of pancreatic and colon cancer cells with C-DIM8 mimics the effects of NR4A1 knockdown and decreases beta1-integrin expression, beta1-integrin regulated genes and responses including migration and adhesion. Nur77 is an orphan receptor and a member of the nerve growth factor-I-B subfamily of the nuclear receptor family of transcription factors. The results demonstrate a novel method for targeting beta1-integrin in colon and pancreatic cancer cells and indicate possible clinical applications for C-DIM/NR4A1 antagonists for pancreatic and colon cancer therapy.
References: J Biol Chem. 2005 Jul 1; 280(26):24903-14; Mol Carcinog. 2017 Sep; 56(9):2066-2075.
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