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akos-b018304

akos-b018304

Item no.	V3990-25mg
Manufacturer	InvivoChem LLC
CASRN	6308-22-1
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3990CAS #:6308-22-1Purity >=98% Description: AKOS B018304, an arylalkylidene derivative with polar substitution at para-position, is a potent inhibitor of chikungunya virus with low micro molar activity. It has antiviral activity against chikungunya virus (LR2006_OPY1) in Vero cell culture by CPE reduction assay. Molecular docking simulation was carried out using the available X-ray crystal structure of the ChikV nsp2 protease, in order to elucidate the possible mechanism of action. Interaction of ligands with ChikV nsp2 protease (PDB Code: 3TRK) suggested the possible mechanism of protease inhibition to act as potent anti-ChikV agents. References: Eur J Med Chem. 2015 Jan 7; 89:172-8
Molecular Weight (MW)	266.30
Formula	C??H?N?O?S?
CAS No.	6308-22-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
Chemical Name	1, 3-thiazolidin-4-one analog
Synonyms	AKOS B018304; AKOS-B018304; AKOSB018304; AKOS B018304; AKOS B 018304; AKOSB 018304; AKOSB-018304
SMILES Code	O=C1NC(S/C1=C/C2=CC=CC=C2[N+]([O-])=O)=S

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Amount: 25mg

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