Comparison

rgx-104

Item no. V3965-500mg
Manufacturer InvivoChem LLC
CASRN 610318-54-2
Amount 500mg
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Available
Description
InvivoChem Cat #:V3965CAS #:610318-54-2 Purity >=98%

Description: RGX-104 (formerly known as SB 742881) is a novel potent and orally available liver-X nuclear hormone receptor-beta (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene. It has potential immunomodulating and antineoplastic activities. RGX-104 selectively targets and binds to LXRbeta, thereby activating LXRbeta-mediated signaling, leading to the transcription of certain tumor suppressor genes and the downregulation of certain tumor promoter genes. This particularly activates the expression of apolipoprotein E (ApoE), a tumor suppressor protein, in tumor cells and certain immune cells. This activates the innate immune system, resulting in depletion of immunosuppressive myeloid-derived suppressor cells (MDSCs), tumor cells and endothelial cells in the tumor microenvironment. This reverses immune evasion, enhances anti-tumor immune responses and inhibits proliferation of tumor cells.

References: 2018 Feb 8; 172(4):825-840.e18.

Related CAS#: 610318-03-1 (HCl)


Molecular Weight (MW)
596.09
Formula
C34H33ClF3NO3
CAS No.
610318-54-2 (free base)
Storage
-20C for 3 years in powder form
-80C for 2 years in solvent
Solubility (In vitro)
DMSO: >= 130 mg/mL
Water: < 1 mg/mL
Ethanol: N/A
Chemical Name
(R)-2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2, 2-diphenylethyl)amino]-3-methylpropoxy]phenyl]acetic acid
Synonyms
SB742881; SB-742881; SB 742881; RGX-104 free form, RGX-104; RGX104; RGX 104
SMILES Code
O=C(O)CC1=CC=CC(OCC[CH](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C3=CC=CC=C3)C4=CC=CC=C4)C)=C1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 500mg
Available: In stock
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