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besifovir-maleate

besifovir-maleate

Item no.	V3956-50mg
Manufacturer	InvivoChem LLC
CASRN	1039623-01-2
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3956CAS #:1039623-01-2 Purity >=98% Description: Besifovir maleate (formerly known as ANA-380 maleate; LB-80380 maleate; PMCDG dipivoxil maleate; Korea Trade name: Besivo) is a reverse transcriptase inhibitor that has been approved in Korea to treat hepatitis B virus (HBV) infection. It is a novel and potent acyclic nucleotide phosphonate with a similar chemical structure to adefovir and tenofovir. Besifovir is a prodrug and an oral nucleotide analogue that inhibits viral replication by incorporation into the viral DNA. Antiviral activity against wild-type virus and virus with drug-resistant mutations was demonstrated in Phase II trials, with significant reduction of viral load in patients treated with LB80380. LB80380 was also shown to be safe and well tolerated. References: Clin Gastroenterol Hepatol. 2018 Nov 15. pii: S1542-3565(18)31244-8; Liver Int. 2016 Jan; 36 Suppl 1:85-92. Related CAS#:441785-26-8 (Besifovir)
Molecular Weight (MW)	627.58
Formula	C26H38N5O11P
CAS No.	1039623-01-2 (Besifovir maleate salt);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
Chemical Name	((((1-((2-amino-9H-purin-9-yl)methyl)cyclopropoxy)methyl)phosphanediyl)bis(oxy))bis(methylene) bis(2, 2-dimethylpropanoate) maleate
Synonyms	LB-80380 maleate; LB 80380; LB80380; ANA-380; AN-380; ANA 380; PMCDG dipivoxil maleate
SMILES Code	NC1=NC=C2N=CN(CC3(OCP(OCOC(C(C)(C)C)=O)OCOC(C(C)(C)C)=O)CC3)C2=N1.O=C(O)/C=C\C(O)=O

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Amount: 50mg

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