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mk-0429

mk-0429

Item no.	V3953-5mg
Manufacturer	InvivoChem LLC
CASRN	227963-15-7
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	227963-15-7
Available
Description	InvivoChem Cat #:V3953CAS #:227963-15-7Purity >=98% Description: MK-0429 is a compound that was originally developed as a selective and potent alphavbeta3 inhibitor for the treatment of osteoporosis, on renal function and fibrosis. MK-0429 is an equipotent pan-inhibitor of multiple av integrins. MK-0429 dose-dependently inhibited podocyte motility and also suppressed TGF-beta-induced fibrosis marker gene expression in kidney fibroblasts. Moreover, in the obese ZSF1 rat model of diabetic nephropathy, chronic treatment with MK-0429 resulted in significant reduction in proteinuria, kidney fibrosis, and collagen accumulation. In summary, inhibition of multiple integrin subtypes might lead to meaningful impact on proteinuria and renal fibrosis in diabetic nephropathy. References: Pharmacol Res Perspect. 2017 Oct; 5(5).
Molecular Weight (MW)	439.51
Formula	C23H29N5O4
CAS No.	227963-15-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
Chemical Name	(S)-3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5, 6, 7, 8-tetrahydro-1, 8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid
Synonyms	MK-0429; MK 0429; MK0429; L-000845704; L 000845704; L000845704
SMILES Code	O=C(O)C[CH](C1=CC=C(OC)N=C1)N2CCN(CCCC3=NC4=C(CCCN4)C=C3)C2=O

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