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ertugliflozin

ertugliflozin

Item no.	V3906-250mg
Manufacturer	InvivoChem LLC
CASRN	1210344-57-2
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3906CAS #:1210344-57-2 Purity >=98% Description: Ertugliflozin (formerly known as also known as PF-04971729; trade name: Steglatro) is an orally active and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2). In 2017, Ertugliflozin was approved by FDA to improve glycemic control in adults with type 2 diabetes mellitus. First-in-human studies after oral administration indicated that the human pharmacokinetics/dose predictions for PF-04971729 were in the range that is likely to yield a favorable pharmacodynamic response. Ertugliflozin (1-25?mg/day) improved glycaemic control, body weight and blood pressure in patients with T2DM suboptimally controlled on metformin, and was well tolerated. References: J Med Chem. 2011 Apr 28; 54(8):2952-60; Drug Metab Dispos. 2013 Feb; 41(2):445-56; Drug Metab Dispos. 2011 Sep; 39(9):1609-19. Related CAS#:1210344-83-4 (Ertugliflozin pidolate)
Molecular Weight (MW)	436.89
Formula	C22H25ClO7
CAS No.	1210344-57-2 (free);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 45 mg/mL
	Water: N/A
	Ethanol: N/A
Chemical Name	1S, 2S, 3S, 4R, 5S)-5-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-1-hydroxymethyl-6, 8-dioxabicyclo(3.2.1)octane-2, 3, 4-triol
Synonyms	PF-04971729; PF 04971729; PF04971729; PF-04971729-00
SMILES Code	O[CH]1[C](O2)(CO)CO[C]2(C3=CC=C(Cl)C(CC4=CC=C(C=C4)OCC)=C3)[CH](O)[CH]1O

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Amount: 250mg

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