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segesterone-acetate

segesterone-acetate

Item no.	V3879-5mg
Manufacturer	InvivoChem LLC
CASRN	7759-35-5
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	7759-35-5
Available
Description	InvivoChem Cat #:V3879CAS #:7759-35-5 Purity >=98% Description: Segesterone acetate (formerly known as ST-1435 or nestorone; trade name: Annovera) is an agonist of progesterone receptor. Segesterone acetate and ethinyl estradiol vaginal system was approved by FDA in August 2018 as new vaginal ring used to prevent pregnancy for an entire year. As a female-contraceptive agent, Segesterone holds back proinflammatory mediators and neuropathology in the wobbler mouse model of motoneuron degeneration. Segesterone protected against hippocampus abnormalities and improved functional outcomes of EAE mice, suggesting its potential value for MS. References: Menopause. 2018 Oct; 25(10):1138-1151.
Molecular Weight (MW)	370.49
Formula	C23H30O4
CAS No.	7759-35-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: < 1mg/mL
	Ethanol: < 1mg/mL
Chemical Name	(8R, 9S, 10R, 13S, 14S, 17R)-17-acetyl-13-methyl-16-methylene-3-oxo-2, 3, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
Synonyms	Elcometrine; Nestorone; segesterone acetate; ST-1435; ST1435; ST1435;
SMILES Code	CC([C]1(OC(C)=O)C(C[C]2([H])[C]3([H])CCC4=CC(CC[C]4([H])[C]3([H])CC[C]12C)=O) =C)=O

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