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Description: Segesterone acetate (formerly known as ST-1435 or nestorone; trade name: Annovera) is an agonist of progesterone receptor. Segesterone acetate and ethinyl estradiol vaginal system was approved by FDA in August 2018 as new vaginal ring used to prevent pregnancy for an entire year. As a female-contraceptive agent, Segesterone holds back proinflammatory mediators and neuropathology in the wobbler mouse model of motoneuron degeneration. Segesterone protected against hippocampus abnormalities and improved functional outcomes of EAE mice, suggesting its potential value for MS.
References: Menopause. 2018 Oct; 25(10):1138-1151.
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