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gs-443902-trisodium-gs-441524-triphosphate-trisodium

gs-443902-trisodium-gs-441524-triphosphate-trisodium

Item no.	V38743-2mg
Manufacturer	InvivoChem LLC
CASRN	1355050-21-3
Amount	2mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V38743CAS #:1355050-21-3Purity >=98% Description: GS-443902 trisodium (GS-441524 trisodium), the trisodiume metabolite (active) of Remdesivir (GS-5734; Veklury) which is an FDA approved drug for treating COVID-19, is a novel highly potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 uM, 5 uM for RSV RdRp and HCV RdRp, respectively. It is the active triphosphate metabolite of Remdesivir. References: 1. Siegel D, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo2, 1-ftriazin-4-amino Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. Med Chem. 2017 Mar 9; 60(5):1648-1661. 2. Cho A, et al. Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7, 9-dideazaadenosine C-nucleosides. Bioorg Med Chem Lett. 2012 Apr 15; 22(8):2705-7. 3. Warren TK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016 Mar 17; 531(7594):381-5. Related CAS#: 1809249-37-3 (Remdesivir); 1191237-69-0 (GS-441524, an active metabolite of Remdesivir) Related CAS#: 1809249-37-3 (Remdesivir); 1191237-69-0 (GS-441524, an active metabolite of Remdesivir)1809249-37-3 (Remdesivir);

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Amount: 2mg

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