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gs-443902

gs-443902

Item no.	V37964-5mg
Manufacturer	InvivoChem LLC
CASRN	1355149-45-9
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V37964CAS #:1355149-45-9Purity >=98% Description: GS443902 (GS-441524 triphosphate), the triphosphate metabolite (active) of Remdesivir (GS-5734; Veklury) which is an FDA approved drug for treating COVID-19, is a novel highly potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 uM, 5 uM for RSV RdRp and HCV RdRp, respectively. It is the active triphosphate metabolite of Remdesivir. References: 1. SiegelD, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of aPyrrolo2, 1-ftriazin-4-amino Adenine C-Nucleoside (GS-5734) for theTreatment of Ebola and Emerging Viruses. Med Chem. 2017 Mar9; 60(5):1648-1661. 2. ChoA, et al. Synthesis and antiviral activity of a series of1'-substituted 4-aza-7, 9-dideazaadenosine C-nucleosides. Bioorg Med ChemLett. 2012 Apr 15; 22(8):2705-7. 3. WarrenTK, et al. Therapeutic efficacy of the small molecule GS-5734 againstEbola virus in rhesus monkeys. Nature. 2016 Mar 17; 531(7594):381-5. Related CAS#: 1809249-37-3 (Remdesivir); 1191237-69-0 (GS-441524, an active metabolite of Remdesivir) Related CAS#: 1809249-37-3 (Remdesivir); 1191237-69-0 (GS-441524, an active metabolite of Remdesivir)1809249-37-3 (Remdesivir);

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Amount: 5mg

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Delivery expected until 9/6/2024