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Description: GS443902 (GS-441524 triphosphate), the triphosphate metabolite (active) of Remdesivir (GS-5734; Veklury) which is an FDA approved drug for treating COVID-19, is a novel highly potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 uM, 5 uM for RSV RdRp and HCV RdRp, respectively. It is the active triphosphate metabolite of Remdesivir.
References:
1. SiegelD, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of aPyrrolo2, 1-ftriazin-4-amino Adenine C-Nucleoside (GS-5734) for theTreatment of Ebola and Emerging Viruses. Med Chem. 2017 Mar9; 60(5):1648-1661.
2. ChoA, et al. Synthesis and antiviral activity of a series of1'-substituted 4-aza-7, 9-dideazaadenosine C-nucleosides. Bioorg Med ChemLett. 2012 Apr 15; 22(8):2705-7.
3. WarrenTK, et al. Therapeutic efficacy of the small molecule GS-5734 againstEbola virus in rhesus monkeys. Nature. 2016 Mar 17; 531(7594):381-5.
Related CAS#: 1809249-37-3 (Remdesivir); 1191237-69-0 (GS-441524, an active metabolite of Remdesivir)
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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Delivery expected until 9/6/2024
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