« Back
Home /
ly3200882

ly3200882

Item no.	V3756-250mg
Manufacturer	InvivoChem LLC
CASRN	1898283-02-7
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3756CAS #: 1898283-02-7Purity >=98% Description: LY3200882 is a next generation, ATP competitive, potent, highly selective small molecule inhibitor of TGF-beta receptor type 1 (TGFbetaRI). It inhibits the serine-threonine kinase domain of TGFbetaRI. LY3200882 inhibits various pro-tumorigenic activities. LY3200882 potently inhibits TGFbeta mediated SMAD phosphorylation in vitro in tumor and immune cells and in vivo in subcutaneous tumors in a dose dependent fashion. In preclinical tumor models, LY3200882 showed potent anti-tumor activity in the orthotopic 4T1-LP model of triple negative breast cancer and this activity correlated with enhanced tumor infiltrating lymphocytes in the tumor microenvironment. References: AACR; Cancer Res 2017; 77(13 Suppl):Abstract nr 955.
Molecular Weight (MW)	435.53
Formula	C24H29N5O3
CAS No.	1898283-02-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 130 mg/mL
	Water: N/A
	Ethanol: N/A
Chemical Name	2-(4-((4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)pyridin-2-yl)propan-2-ol
Synonyms	LY 3200882; LY3200882; LY-3200882;

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 250mg

available

Delivery expected until 9/6/2024

Express Delivery: Save 17 days

Compare

Add to wishlist

Recommend by mail