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succinobucol

succinobucol

Item no.	V3733-250mg
Manufacturer	InvivoChem LLC
CASRN	216167-82-7
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3733CAS #:216167-82-7 Purity >=98% Description: Succinobucol (formerly known as AGI-1067, AGZ-1067, Probucol monosuccinate, succinyl ester of probucol) is a a lipid-lowering compound and a phenolic antioxidant with anti-inflammatory and antiplatelet effects. Succinobucol inhibits TLR4 ligand (LPS)-induced activation of ASK1 and the downstream p38 and JNK MAP kinases, which could inhibit ASK1-JNK/p38-dependent gene expression of proinflamamtory molecules. Inhibition of both p38 and JNK by AGI-1067 occurred in a concentration-dependent manner with an IC50 value under 5 uM. AtheroGenics reports positive results from ANDES Phase 3 Clinical Trial (NCT00066898) of Succinobucol. References: Mol Neurobiol. 2016 Mar; 53(2):1280-95; Platelets. 2017 May; 28(3):295-300.
Molecular Weight (MW)	616.92
Formula	C35H52O5S2
CAS No.	216167-82-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water:
	Ethanol:
Chemical Name	4-(4-((1-((3, 5-bis(1, 1-Dimethylethyl)-4-hydroxyphenyl)sulfanyl)-1-methylethyl)sulfanyl)-2, 6-bis(1, 1-dimethylethyl)phenoxy)-4-oxobutanoic acid
Synonyms	Probucol monosuccinate; Succinobucol; AGI-1067; AGZ-1067; AGI1067; AGZ1067; AGZ-1067; AGZ 1067.

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Amount: 250mg

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Delivery expected until 9/6/2024