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lenvatinib-mesylate

lenvatinib-mesylate

Item no.	V3700-25mg
Manufacturer	InvivoChem LLC
CASRN	857890-39-2
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	857890-39-2
Available
Description	InvivoChem Cat #:V3700CAS #:857890-39-2 Purity >=98% Description: Lenvatinib (also known as E7080, ER-203492-00) is a multi-targeted, orally bioavailable inhibitor of VEGFR2(KDR)/VEGFR3(Flt-4) for the most part with potential antineoplastic activity. It has IC50 values of 4 nM/5.2 nM for VEGFR2/VEGFR3 respectively, it is less potent against VEGFR1/Flt-1, and is ca.10-fold more selective for VEGFR2/3 against FGFR1, PDGFRalpha/beta in cell-free assays. Lenvatinib is currently undergoing investigation both as monotherapy and in combination with cytotoxic agents for various types of solid tumor, including thyroid carcinoma and hepatocellular carcinoma (in Phase III trials), and melanoma, renal carcinoma, non-small cell lung carcinoma etc. References: Int J Cancer. 2008 Feb 1; 122(3):664-71; Clin Cancer Res. 2008 Sep 1; 14(17):5459-65. Related CAS#:417716-92-8 (free base)
Molecular Weight (MW)	522.96
Formula	C22H23ClN4O7S
CAS No.	857890-39-2 (mesylate);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 100 mg/mL
	Water:
	Ethanol:
Solubility (In vivo)	0.5% methylcellulose: 30 mg/kg
Synonyms	E-7080 mesylate; E7080; E 7080; ER-203492-00 mesylate; Lenvatinib mesylate ; Brand name Lenvima

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Amount: 25mg

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