nnc-55-0396

InvivoChem Cat #:V3671CAS #:357400-13-6 Purity >=98%

Description: NNC 55-0396 dihydrochloride salt, an analog of mibefradil, is a novel, potent and highly selective T-type calcium channel blocker which displays IC50 values of 6.8 and > 100 uM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells. As a T-type calcium channel blocker, NNC 55-0396 inhibits angiogenesis via suppression of hypoxia-inducible factor-1alpha signal transduction. NNC 55-0396 suppressed mitochondrial reactive oxygen species-mediated HIF-1alpha expression as well as stabilization by inhibiting protein synthesis in a dose-dependent manner. NNC 55-0396 inhibited tumor-induced angiogenesis in vitro and in vivo by suppressing HIF-1alpha stability. NNC 55-0396 could be a potential therapeutic drug candidate for cancer treatment.

References: European Journal of Pharmacology. 2011, 659 (1): 30-36.; Pharmacology Biochemistry and Behavior. 2011, 97(4): 656-659.

Related CAS#:357400-14-7 (free base)

-20C for 3 years in powder form

Synonym: NNC 55-0396 HCl; NNC55-0396 2HCl; NNC-55-0396 diHCl; NNC-550396; NNC550396; NNC 550396; NNC 55-0396 dihydrochloride
IUPAC/Chemical Name: (1S, 2S)-2-(2-((3-(1H-benzo[d]imidazol-2-yl)propyl)(methyl)amino)ethyl)-6-fluoro-1-isopropyl-1, 2, 3, 4-tetrahydronaphthalen-2-yl cyclopropanecarboxylate dihydrochloride
InChi Key: BCCQNBXHUMKLFW-HNQRYHMESA-N
InChi Code: InChI=1S/C30H38FN3O2.2ClH/c1-20(2)28-24-13-12-23(31)19-22(24)14-15-30(28, 36-29(35)21-10-11-21)16-18-34(3)17-6-9-27-32-25-7-4-5-8-26(25)33-27; ; /h4-5, 7-8, 12-13, 19-21, 28H, 6, 9-11, 14-18H2, 1-3H3, (H, 32, 33); 2*1H/t28-, 30-; ; /m0../s1
SMILES Code: CC([CH]1C2=C(C=C(F)C=C2)CC[C]1(OC(C3CC3)=O)CCN(CCCC4=NC5=CC=CC=C5N4)C)C.Cl.Cl