ro8994

InvivoChem Cat #:V3661CAS #:1309684-94-3 Purity >=98%

Description: RO8994, a spiroindolinone-based compound, is a novel, highly potent and selective small-molecule inhibitor of p53/MDM2 interaction with IC50 of 5 nM in a HTRF binding assay and 20 nM in a MTT proliferation assay. RO8994 can be potentially useful for cancer therapy. At variance to solid tumors, which show percentage of p53 deletions and/or mutations close to 50%, more than 80% of haematological malignancies express wild-type p53 at diagnosis. Therefore, activation of the p53 pathway by antagonizing its negative regulator murine double minute 2 (MDM2) might offer a new therapeutic strategy for the great majority of haematological malignancies.

References: Bioorg Med Chem. 2014 Aug 1; 22(15):4001-4009.

-20C for 3 years in powder form

Synonym: RO8994; RO-8994; RO 8994.
Chemical Name: (2'S, 3R, 4'R, 5'R)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3, 3'-pyrrolidine]-5'-carboxamide
InChi Key: MURAVORBGFDSMA-KTHXJTJTSA-N
InChi Code: InChI=1S/C31H31Cl2FN4O4/c1-30(2, 3)14-23-31(18-10-9-16(32)13-21(18)37-29(31)41)24(17-6-5-7-19(33)25(17)34)26(38-23)28(40)36-20-11-8-15(27(35)39)12-22(20)42-4/h5-13, 23-24, 26, 38H, 14H2, 1-4H3, (H2, 35, 39)(H, 36, 40)(H, 37, 41)/t23-, 24+, 26+, 31+/m0/s1
SMILES Code: O=C([CH](N[CH]1CC(C)(C)C)[CH](C2=CC=CC(Cl)=C2F)[C]31C(NC4=C3C=CC(Cl)=C4)=O)NC5=CC=C(C(N)=O)C=C5OC