Item no. |
V3502-250mg |
Manufacturer |
InvivoChem LLC
|
CASRN |
1256918-39-4 |
Amount |
250mg |
Category |
|
Type |
Biochemicals |
Specific against |
other |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Available |
|
Description |
InvivoChem Cat #:V3502CAS #:1256918-39-4 Purity >=98%Description: BMS-852927 (also known as XL041) is a partial agonist of LXRbeta (liver X receptor beta). BMS-852927 had favorable profiles in animal models with a wide therapeutic index in cynomolgus monkeys and mice. In healthy subjects and hypercholesterolemic patients, reverse cholesterol transport pathways were induced similarly to that in animal models. However, increased plasma and hepatic TG, plasma LDL-C, apoB, apoE, and CETP and decreased circulating neutrophils were also evident. Furthermore, similar increases in LDL-C were observed in normocholesterolemic subjects and statin-treated patients. The primate model markedly underestimated human lipogenic responses and did not predict human neutrophil effects. These studies demonstrate both beneficial and adverse LXR agonist clinical responses and emphasize the importance of further translational research in this area. References: Cell Metab. 2016 Aug 9; 24(2):223-33. |
|
Name: BMS-852927 CAS#: 1256918-39-4 Chemical Formula: C29H28Cl2F2N2O4S Exact Mass: 608.1115 Molecular Weight: 609.5098 Elemental Analysis: C, 57.15; H, 4.63; Cl, 11.63; F, 6.23; N, 4.60; O, 10.50; S, 5.26 |
Storage |
-20C for 3 years in powder form |
|
-80C for 2 years in solvent |
Technical Information |
Synonym: BMS-852927; BMS 852927; BMS852927; XL041; XL-041; XL 041. Chemical Name: 2-(2-(2-(2, 6-dichlorophenyl)propan-2-yl)-1-(3, 3?-difluoro-4?-(hydroxymethyl)-5?-(methylsulfonyl)biphenyl-4-yl)-1H-imidazol-4-yl)propan-2-ol InChi Key: HNAJDMYOTDNOBK-UHFFFAOYSA-N InChi Code: InChI=1S/C29H28Cl2F2N2O4S/c1-28(2, 26-19(30)7-6-8-20(26)31)27-34-25(29(3, 4)37)14-35(27)23-10-9-16(11-22(23)33)17-12-21(32)18(15-36)24(13-17)40(5, 38)39/h6-14, 36-37H, 15H2, 1-5H3 SMILES Code: CC(O)(C1=CN(C2=CC=C(C3=CC(S(=O)(C)=O)=C(CO)C(F)=C3)C=C2F)C(C(C)(C4=C(Cl)C=CC=C4Cl)C)=N1)C |
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