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bms-830216

bms-830216

Item no.	V3469-100mg
Manufacturer	InvivoChem LLC
CASRN	1197420-06-6
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3469CAS #:1197420-06-6 Purity >=98% Description: BMS-830216 is a prodrug of BMS-819881 which is a novel and potent antagonist of MCHR1 (Melanin concentrating hormone receptor 1) with minimal hERG activity. It binds to rat MCHR1 with a Ki of 7 nM and is also selective for CYP3A4 activity with an EC50 of 13 uM. BMS-819881 has the potential to be used as an anti-obesity drug. It is currently under investigation in Phase 1 clinical trial for treating obesity as the phosphate ester pro-drug (BMS-830216). References: J Med Chem. 2014 Sep 25; 57(18):7509-22.
	Name: BMS-830216 CAS#: 1197420-06-6 Chemical Formula: C24H22ClN2O7PS Exact Mass: 548.0574 Molecular Weight: 548.93 Elemental Analysis: C, 52.51; H, 4.04; Cl, 6.46; N, 5.10; O, 20.40; P, 5.64; S, 5.84
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: BMS-830216; BMS 830216; BMS830216 Chemical Name: (R)-2-(4-(6-(4-Chlorophenyl)-4-oxothieno[3, 2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethyl dihydrogen phosphate InChi Key: YDTUJCNTIMWHPJ-NRFANRHFSA-N InChi Code: InChI=1S/C24H22ClN2O7PS/c1-32-20-10-17(8-9-19(20)33-12-21(14-2-3-14)34-35(29, 30)31)27-13-26-18-11-22(36-23(18)24(27)28)15-4-6-16(25)7-5-15/h4-11, 13-14, 21H, 2-3, 12H2, 1H3, (H2, 29, 30, 31)/t21-/m0/s1 SMILES Code: O=P(O)(O[CH](C1CC1)COC2=CC=C(N(C=NC3=C4SC(C5=CC=C(Cl)C=C5)=C3)C4=O)C=C2OC)O

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Amount: 100mg

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Delivery expected until 9/6/2024

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