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bms-986169

bms-986169

Item no.	V3465-10mg
Manufacturer	InvivoChem LLC
CASRN	1801151-08-5 (BMS-986169); 1801151-09-6 (BMS-986163, prodrug of BMS-986169)
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3465CAS #:1801151-08-5 (BMS-986169); 1801151-09-6 (BMS-986163, prodrug of BMS-986169)Purity >=98% Description: BMS-986169 is a novel and potent negative allosteric modulator of GluN2B which is a N-methyl-d-aspartate receptor subtype. BMS-986169 has potential to be used in major depressive disorder. BMS-986169 exhibited high binding affinity for the GluN2B allosteric site (Ki = 4.0 nM) and selective inhibition of GluN2B receptor function (IC50 = 24 nM) in cells. BMS-986169 has demonstrated an acceptable safety and toxicology profile and was selected as a preclinical candidate for further evaluation in major depressive disorder. References: ACS Med Chem Lett. 2018 Apr 13; 9(5):472-477.
	Name: BMS-986169 CAS#: 1801151-08-5 Chemical Formula: C23H27FN2O2 Exact Mass: 382.2057 Molecular Weight: 382.4794 Elemental Analysis: C, 72.23; H, 7.12; F, 4.97; N, 7.32; O, 8.37
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: BMS-986169; BMS 986169; BMS986169 Chemical Name: (R)-3-((3S, 4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one InChi Key: UNVYDSCXINFREZ-BHDDXSALSA-N InChi Code: InChI=1S/C23H27FN2O2/c1-16-2-4-17(5-3-16)14-26-13-11-22(23(26)28)25-12-10-20(21(24)15-25)18-6-8-19(27)9-7-18/h2-9, 20-22, 27H, 10-15H2, 1H3/t20-, 21+, 22+/m0/s1 SMILES Code: O=C1N(CC2=CC=C(C)C=C2)CC[CH]1N3C[CH](F)[CH](C4=CC=C(O)C=C4)CC3

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Amount: 10mg

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Delivery expected until 10/4/2024

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