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mk-6096

mk-6096

Item no.	V3447-250mg
Manufacturer	InvivoChem LLC
CASRN	1088991-73-4
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3447CAS #:1088991-73-4 Purity >=98% Description: Filorexant (formerly known as MK-6096) is a novel, orally bioavailable, potent and selective reversible antagonist of OX(1)R and OX(2)R currently in clinical development for insomnia. In radioligand binding and functional cell based assays, MK-6096 demonstrated potent binding and antagonism of both human OX(1)R and OX(2)R. MK-6096 occupies 90% of human OX(2)Rs expressed in transgenic rats at a plasma concentration of 142 nM, and dose-dependently reduced locomotor activity and significantly increased sleep in rats (3-30 mg/kg) and dogs (0.25 and 0.5 mg/kg). MK-6096 represents a novel and selective therapeutic for the treatment of insomnia. References: Neuropharmacology. 2012 Feb; 62(2):978-87; ChemMedChem. 2012 Mar 5; 7(3):415-24, 337.
Molecular Weight (MW)	420.49
Formula	C24H25FN4O2
CAS No.	1088991-73-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 10mg/mL
	Water: N/A
	Ethanol: N/A
Chemical Name	((2R, 5R)-5-(((5-fluoropyridin-2-yl)oxy)methyl)-2-methylpiperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone
Synonyms	MK-6096; MK6096; MK 6096
SMILES Code	O=C(N1[CH](C)CC[CH](COC2=NC=C(F)C=C2)C1)C3=CC(C)=CC=C3C4=NC=CC=N4

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