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Description: Fenoldopam hydrochloride (SKF-82526) is a synthetic benzazepine analog acting as a selective D1 receptor partial agonist. It was approved by the Food and Drug Administration (FDA) in September 1997 as an antihypertensive agent. Since fenoldopam is the only intravenous agent that improves renal perfusion, in theory it could be beneficial in hypertensive patients with concomitant renal insufficiency.
References:
1. Grenader, A. and D.P. Healy, Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther, 1991. 258(1): p. 193-8.
2. Nichols, A.J., R.R. Ruffolo, Jr., and D.P. Brooks, The pharmacology of fenoldopam. Am J Hypertens, 1990. 3(6 Pt 2): p. 116S-119S.
Related CAS#: 67287-54-1 (HBr) 181217-39-0 (HCl) 67227-57-0 (mesylate) 67227-56-9 (free base)
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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