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arn14974

arn14974

Item no.	V3381-250mg
Manufacturer	InvivoChem LLC
CASRN	1644158-57-5
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3381CAS #:1644158-57-5 Purity >=98% Description: ARN14974, a benzoxazolone carboxamide analog, is a novel and potent inhibitor of acid ceramidase with IC50 of 79 nM. It inhibits acid ceramidase activity, reduces levels of sphingosine and dihydroceramide, and increases levels of ceramide in SW403 adenocarcinoma cells and RAW 264.7 murine macrophages when used at concentrations ranging from 0.1 to 20 mM. In vivo, ARN14974 (10 mg/kg, i.v.) reduces acid ceramidase activity in multiple organs, including brain, liver, heart, lungs, and kidney, and increases pulmonary ceramide levels in mice. References: Angewandte Chemistry International Edition English 54(2), 485-489 (2014).
	Name: ARN14974 CAS#: 1644158-57-5 Chemical Formula: C24H21FN2O3 Exact Mass: 404.1536 Molecular Weight: 404.4414 Elemental Analysis: C, 71.27; H, 5.23; F, 4.70; N, 6.93; O, 11.87
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: ARN14974; ARN-14974; ARN 14974; Acid Ceramidase Inhibitor 17a; Chemical Name: 6-(4-fluorophenyl)-2-oxo-N-(4-phenylbutyl)-3(2H)-benzoxazolecarboxamide InChi Key: DPYVAZSLMQCVOG-UHFFFAOYSA-N InChi Code: InChI=1S/C24H21FN2O3/c25-20-12-9-18(10-13-20)19-11-14-21-22(16-19)30-24(29)27(21)23(28)26-15-5-4-8-17-6-2-1-3-7-17/h1-3, 6-7, 9-14, 16H, 4-5, 8, 15H2, (H, 26, 28) SMILES Code: O=C(N1C(OC2=CC(C3=CC=C(F)C=C3)=CC=C12)=O)NCCCCC4=CC=CC=C4

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Amount: 250mg

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Delivery expected until 10/4/2024

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