chz868

Item no.	V3373-50mg
Manufacturer	InvivoChem LLC
CASRN	1895895-38-1
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3373CAS #:1895895-38-1Purity >=98% Description: CHZ868 is a novel, potent and selective type II JAK2 inhibitor with an IC50 of 0.17 uM in EPOR JAK2 WT Ba/F3 cell. It stabilizes JAK2 in an inactive conformation. CHZ868 potently suppressed the growth of CRLF2-rearranged human B-ALL cells, abrogated JAK2 signaling, and improved survival in mice with human or murine B-ALL. CHZ868 and dexamethasone synergistically induced apoptosis in JAK2-dependent B-ALLs and further improved in vivo survival compared to CHZ868 alone. These data support the testing of type II JAK2 inhibition in patients with JAK2-dependent leukemias and other disorders. Description: References: Cancer Cell. 2015 Jul 13; 28(1):29-41; Cancer Cell. 2015 Jul 13; 28(1):15-28. References:
	Name: CHZ868 CAS#: 1895895-38-1 Chemical Formula: C22H19F2N5O2 Exact Mass: 423.15068 Molecular Weight: 423.42 Elemental Analysis: C, 62.41; H, 4.52; F, 8.97; N, 16.54; O, 7.56
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: CHZ868; CHZ 868; CHZ-868 Chemical Name: N-(4-((2-((2, 4-difluorophenyl)amino)-1, 4-dimethyl-1H-benzo[d]imidazol-5-yl)oxy)pyridin-2-yl)acetamide InChi Key: KQQLBXFPTDVFAJ-UHFFFAOYSA-N InChi Code: InChI=1S/C22H19F2N5O2/c1-12-19(31-15-8-9-25-20(11-15)26-13(2)30)7-6-18-21(12)28-22(29(18)3)27-17-5-4-14(23)10-16(17)24/h4-11H, 1-3H3, (H, 27, 28)(H, 25, 26, 30) SMILES Code: CC(NC1=NC=CC(OC2=CC=C3N(C)C(NC4=CC=C(F)C=C4F)=NC3=C2C)=C1)=O

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Amount: 50mg

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Delivery expected until 10/4/2024

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