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sb-649868

sb-649868

Item no.	V3343-250mg
Manufacturer	InvivoChem LLC
CASRN	380899-24-1
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3343CAS #:380899-24-1 Purity >=98% Description: SB-649868 (GSK-649868) is a novel, potent, selective and orally bioactive orexin (OX) 1 and OX2 receptor antagonist with pKi of 9.4 and 9.5 for OX1 and OX2 receptor, respectively. It can be potentially used for the treatment of insomnia and sleep disorder. The hypothalamic peptides orexin-A and orexin-B are potent agonists of two G-protein coupled receptors, namely the OX(1) and the OX(2) receptor. These receptors are widely distributed, though differentially, in the rat brain. In particular, the OX(1) receptor is highly expressed throughout the hypothalamus, whilst the OX(2) receptor is mainly located in the ventral posterior nucleus. Description: References: Eur J Pharmacol. 2012 Oct 5; 692(1-3):1-9; Bioorg Med Chem Lett. 2011 Sep 15; 21(18):5562-7. References:
Molecular Weight (MW)	477.55
Formula	C26H24FN3O3S
CAS No.	380899-24-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
Chemical Name	(S)-N-((1-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)piperidin-2-yl)methyl)benzofuran-4-carboxamide
Synonyms	SB649868; SB-649868; SB 649868; GSK-649868; GSK-649868; GSK649868
SMILES Code	O=C(C1=C2C=COC2=CC=C1)NC[CH]3N(C(C4=C(C5=CC=C(F)C=C5)SC(C)=N4)=O)CCCC3

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250mg

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Delivery expected until 9/6/2024

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