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Description: MC 1046 is a major impurity of Calcipotriol (MC 903; Calcipotriene) which is an agonist/ligand of VDR-like receptors.
References:
1. Binderup(1993) Comparison of calcipotriol with selected metabolites andanalogues of vitamin D3: effects on cell growth regulation in vitro andcalcium metabolism in vivo. Pharmacol.Toxicol. 72 240.
2. Knutsonet al (1997) Pharmacokinetics and systemic effect on calciumhomeostasis of 1a, 24-dihydroxyvitamin D2 in rats. Biochem.Pharmacol. 53829.
3. Wietrzyk et al (2007) Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 447.111
4. P.J.Marie, D. Connes, M. Hott, L. Miravet. Comparative effects of a novelVitamin D Analogue MC-903 and 1, 25-dihydroxyvitamin D3 on alkalinephosphatase activity, osteocalcin and DNA synthesis by humanosteoblastic cells in culture. Bone. Volume 11, Issue 3, 1990, Pages171-179
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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