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cebranopadol-hemicitrate

cebranopadol-hemicitrate

Item no.	V3265-25mg
Manufacturer	InvivoChem LLC
CASRN	863513-92-2 (hemicitrate salt);
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3265CAS #:863513-92-2 (hemicitrate salt); Purity >=98% Description: Cebranopadol hemicitrate, the hemicitrate salt of Cebranopadol (also known as GRT-6005), is a novel, first in class compound with potent agonist activity on ORL-1 (opioid receptor like -1) and the well established mu opioid receptor. Cebranopadol is an analgesic nociceptin/orphanin FQ peptide (NOP) that exhibits high potency and efficacy in several rat models of acute and chronic pain (tail-flick, rheumatoid arthritis, bone cancer, spinal nerve ligation, diabetic neuropathy) with ED50 values of 0.5-5.6 ug/kg after intravenous and 25.1 ug/kg after oral administration. It is being evaluated in clinical Phase 2 and Phase 3 trials for the treatment of chronic and acute pain. Recent evidence indicates that the combination of opioid and NOP receptor agonism may be a new treatment strategy for cocaine addiction. Description: References: J Pharmacol Exp Ther. 2014 Jun; 349(3):535-48; J Pharmacol Exp Ther. 2017 Sep; 362(3):378-384. References: Related CAS:863513-91-1 (free); 863513-93-3 ((1alpha, 4alpha)stereoisomer)
Molecular Weight (MW)	949.09
Formula	C54H62F2N4O9
CAS No.	863513-92-2 (hemicitrate salt); 863513-91-1 (free)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 10mM
	Water: N/A
	Ethanol: N/A
Chemical Name	6-fluoro-N, N-dimethyl-1'-phenylspiro[4, 9-dihydro-3H-pyrano[3, 4-b]indole-1, 4'-cyclohexane]-1'-amine, 2-hydroxypropane-1, 2, 3-tricarboxylic acid
Synonyms	Cebranopadol; GRT6005 hemicitrate; GRT 6005 hemicitrate; GRT-6005 hemicitrate; Cebranopadol hemicitrate; GRT-6005; GRT 6005; GRT6005;

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Amount: 25mg

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Delivery expected until 10/4/2024

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