banoxantrone-d12-dihydrochloride

Description: Banoxantrone D12 dihydrochloride (AQ4N D12) is the deuterium labeled banoxantrone(AQ4N), which is a novel and potent bioreductive prodrug that can be reducedunder hypoxia to a stable, DNA-affinic compound AQ4 (CAS#: 70476-63-0), which is a potent topoisomerase II inhibitor with antineoplastic activity. Banoxantroneintercalates into and crosslinks DNA, and inhibits topoisomerase II.This results in an inhibition of DNA replication and repair in tumorcells. Combined with conventional therapeutic agents, both oxygenic andhypoxic regions of tumors can be targeted.

References:

1. HejmadiMV, et al. DNA damage following combination of radiation with thebioreductive drug AQ4N: possible selective toxicity to oxic and hypoxictumour cells. Br J Cancer. 1996 Feb; 73(4):499-505.

2. ManleyE Jr, et al. Impact of tumor blood flow modulation on tumor sensitivityto the bioreductive drug banoxantrone. J Pharmacol Exp Ther. 2013Feb; 344(2):368-77.

3. WilliamsKJ, et al. In vivo activation of the hypoxia-targeted cytotoxin AQ4N inhuman tumor xenografts. Mol Cancer Ther. 2009 Dec; 8(12):3266-75.

Related CAS: 136470-65-0 (Banoxantrone Free base); 70476-63-0 (Banoxantrone AQ4); 252979-56-9 (2HCl); 1562066-98-1 (AQ4N D12)