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vuf10460

vuf10460

Item no.	V3236-250mg
Manufacturer	InvivoChem LLC
CASRN	1028327-66-3
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3236CAS #:1028327-66-3Purity >=98% Description: VUF10460 is a non-imidazole agonist of the histamine H4 receptor which binds to rat H4 receptor with a pKi of 7.46. Radioligand binding studies showed that VUF10460 displayed approximately a 50-fold selectivity for the rat H4 receptor over the H3 receptor, VUF10460, possibly due to the lack of imidazole heterocycle. In conscious rats, immethridine and methimepip significantly reduced (66% and 48% inhibition, respectively) the gastric lesions induced by HCl; HCl-induced lesions were also significantly enhanced by the H4 receptor agonists VUF10460 and VUF8430, suggesting the activation of histamine H4 receptors by the selective agonists VUF10460 and VUF8430 aggravated the ulcerogenic effects of 0.6 N HCl. Description: References: Pharmacology. 2012; 89(5-6):287-94; Eur J Pharmacol. 2011 Nov 1; 669(1-3):121-7. References:
Molecular Weight (MW)	269.34
Formula	C??H??N?
CAS No.	1028327-66-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 30 mg/mL
	Water: N/A
	Ethanol: N/A
Chemical Name	4-(4-methylpiperazin-1-yl)-6-phenylpyrimidin-2-amine
Synonyms	VUF10460; VUF-10460; VUF 10460
SMILES Code	NC1=NC(C2=CC=CC=C2)=CC(N3CCN(C)CC3)=N1

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Amount: 250mg

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