nsc632839

Description: NSC632839 is a nonselective isopeptidase inhibitor that inhibits USP2, USP7, and SENP2 with EC50 values of 45+/-4 uM, 37+/-1 uM, and 9.8+/-1.8 uM, respectively. NSC632839 is not only a DUB (deubiquitylases) inhibitor, but also a deSUMOylase inhibitor. Conjugation or deconjugation of ubiquitin (Ub) or ubiquitin-like proteins (UBLs) to or from cellular proteins is a multifaceted and universal means of regulating cellular physiology, controlling the lifetime, localization, and activity of many critical proteins. Deconjugation of Ub or UBL from proteins is performed by a class of proteases called isopeptidases. The inhibitory activity of the nonselective isopeptidase inhibitor NSC 632839 against deubiquitylases and deSUMOylases was profiled.

References: Protein Sci. 2008 Jun; 17(6):1035-43.