lp-211

Item no.	V3191-100mg
Manufacturer	InvivoChem LLC
CASRN	1052147-86-0
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3191CAS #:1052147-86-0 Purity >=98% Description: LP-211 is a potent and selective 5-HT7 receptor agonist with a Ki of 0.58 nM at rat cloned 5-HT7 receptors. It has high selectivity over 5-HT1A receptor (Ki of 188 nM) and D2 receptor (Ki=142 nM)((324- and 245-fold, respectively)). LP-211 is able to cross blood?brain barrier and has agonist properties (maximal effect = 82%, EC 50 = 0.60 microM). After intraperitoneal injection in mice, LP-211 rapidly reached the systemic circulation and entered the brain. Its brain concentration-time profile paralleled that in plasma, indicating that LP-211 rapidly and freely distributes across the blood-brain barrier. LP-211 is metabolized via N-dealkylation to the corresponding 1-arylpiperazine metabolite. Description: References: J Med Chem. 2008 Sep 25; 51(18):5813-22; Am J Transl Res. 2016 Jun 15; 8(6):2525-33; Synapse. 2017 Dec; 71(12). doi: 10.1002/syn.21995. References:
Molecular Weight (MW)	466.63
Formula	C30H34N4O
CAS No.	1052147-86-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 100 mg/mL
	Water:
	Ethanol:
Chemical Name	N-[(4-cyanophenyl)methyl]-6-[4-(2-phenylphenyl)piperazin-1-yl]hexanamide
Synonyms	LP 211; LP211; LP-211
SMILES Code	O=C(NCC1=CC=C(C#N)C=C1)CCCCCN2CCN(C3=CC=CC=C3C4=CC=CC=C4)CC2

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