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glecaprevir

glecaprevir

Item no.	V3171-500mg
Manufacturer	InvivoChem LLC
CASRN	1365970-03-1
Amount	500mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3171CAS #:1365970-03-1Purity >=98% Description: Glecaprevir (previously known as ABT-493 and/or A-1282576; trade name: Mavyret) is a novel and potent inhibitor of the HCV NS3/4A protease (HCV: hepatitis C virus; NS: nonstructural) with IC50 ranging from 3.5 to 11.3 nM. Glecaprevir has the potential to be used as an anti-HCV agent and is currently undergoing phase 3 clinical trials for HCV treatment by AbbVie. Glecaprevir is a direct-acting antiviral (DAA) which demonstrated potent antiviral activity against major HCV genotypes and high barriers to resistance in vitro. It also exhibited an acceptable safety profile during a 3-day monotherapy in patients with HCV genotype 1 infection, with or without compensated cirrhosis. In August 2017, the U.S. Food and Drug Administration approved the combination drug glecaprevir/pibrentasvir (trade name Mavyret) for the treatment of all major genotypes (1–6) of chronic hepatitis C. Description: References: Antimicrob Agents Chemother. 2017; 62(1). pii: e01620-17; Antimicrob Agents Chemother. 2015; 60(3):1546-55. References: Related CAS#: 1838572-01-2 (hydrate)
Molecular Weight (MW)	838.87
Formula	C38H46F4N6O9S
CAS No.	1365970-03-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 80 mg/mL
	Water: N/A
	Ethanol: N/A
Chemical Name	33R, 35S, 91R, 92R, 5S, E)-5-(tert-butyl)-N-((1R, 2R)-2-(difluoromethyl)-1-(((1-methylcyclopropyl)sulfonyl)carbamoyl)cyclopropyl)-14, 14-difluoro-4, 7-dioxo-2, 8, 10-trioxa-6-aza-1(2, 3)-quinoxalina-3(3, 1)-pyrrolidina-9(1, 2)-cyclopentanacyclotetradecaphan-12-ene-35-carboxamide
Synonyms	ABT493; A1282576; ABT-493; A-1282576; ABT 493; A 1282576
SMILES Code	O=C([CH]1N(C([CH](NC(O[C]2([H])[C]3([H])CCC2)=O)C(C)(C)C)=O)C[C](OC4=NC5=CC=CC=C5N=C4C(F)(/C=C/CO3)F)([H])C1)N[C]6([CH](C(F)F)C6)C(NS(=O)(C7(CC7)C)=O)=O

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Amount: 500mg

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