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Description: Vildagliptin (LAF237 dihydrate; NVP-LAF 237 dihydrate) is a selective dipeptidyl peptidase 4 (DPP4) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. It delays the degradation of glucagon-like peptide-1 (GLP-1).Vildagliptin dihydrate possesses excellent oral bioavailability andpotent antihyperglycemic activity.
References:
1. ChengQ, et al. Combination of the dipeptidyl peptidase IV inhibitor LAF237(S)-1-(3-hydroxy-1-adamantyl)ammoacetyl-2-cyanopyrrolidine with theangiotensin II type 1 receptor antagonist valsartanN-(1-oxopentyl)-N-2'-(1H-tetrazol-5-yl)-1, 1'-biphenyl-4-ylmethyl-L-valineenhances pancreatic islet morphology and function in a mouse model oftype 2 diabetes. J Pharmacol Exp Ther. 2008 Dec; 327(3):683-91.
2. ShenM, et al. The synergistic effect of valsartan and LAF237(S)-1-(3-hydroxy-1-adamantyl)ammoacetyl-2-cyanopyrrolidine onvascular oxidative stress and inflammation in type 2 diabetic mice. ExpDiabetes Res. 2012; 2012:146194.
3. AbdelhamidAM, et al. Vildagliptin/Pioglitazone Combination Improved The OverallGlycemic Control In Type I Diabetic Rats. Can J Physiol Pharmacol. 2018Mar 6. doi: 10.1139/cjpp-2017-0680.
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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