md-224

Item no.	V31651-10mg
Manufacturer	InvivoChem LLC
CASRN	2136247-12-4
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V31651CAS #:2136247-12-4 Purity >=98% Description: MD-224 is a novel, first-in-class and potent PROTAC molecule targeting human murine double minute 2 (MDM2) for degradation, it has the potential to be used as a new class of anticancer agent. It is able to induce rapid degradation of MDM2 protein at a concentration of< 1 nM in human leukemia cells, and has an antiproliferative IC50 value of 1.5 nM for inhibiting the growth of RS4; 11 cells. References: Discoveryof MD-224 as a First-in-Class, Highly Potent, and EfficaciousProteolysis TargetingChimera Murine Double Minute 2 Degrader Capable ofAchieving Complete and Durable TumorRegression. J Med Chem. 2019 Jan24; 62(2):448-466

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