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uk-371804

uk-371804

Item no.	V3165-5mg
Manufacturer	InvivoChem LLC
CASRN	256477-09-5
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3165CAS #:256477-09-5Purity >=98% Description: UK-371804 is a potent and selective inhibitor of urokinase-type plasmogen activator (uPA) with excellent potency (Ki=10 nM in an enzyme assay) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 microM) in vitro. In a porcine acute excisional wound model in vivo, upon topical administration, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse side effects on wound healing parameters. Description: References: J Med Chem. 2007 May 17; 50(10):2341-51. References: Related CAS#:256476-36-5 (HCl)
Molecular Weight (MW)	385.82
Formula	C14H16ClN5O4S
CAS No.	256477-09-5;
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 42 mg/mL (99.5 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
SMILES Code	CC(C)(NS(=O)(C1=CC2=C(C=C1)C(Cl)=CN=C2/N=C(N)\N)=O)C(O)=O
Synonyms	UK371804; UK-371804; UK 371804; UK-371, 804; UK 371, 804; UK371, 804.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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