gcn2ib

Item no.	V31579-10mg
Manufacturer	InvivoChem LLC
CASRN	2183470-12-2
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V31579CAS #:2183470-12-2Purity >=98% Description: GCN2iB is a novel, potent and ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2) with an IC50 of 2.4 nM. GCN2iB has the potential to be used for the treatment of cancer. The inhibition of GCN2sensitizes cancer cells with low basal-level expression of asparaginesynthetase (ASNS) to the antileukemic agent L-asparaginase (ASNase) invitro and in vivo. References: Inhibitionof GCN2 sensitizes ASNS-low cancer cells by disrupting the amino acidresponse. Proc Natl Acad Sci U S A. 2018 Aug 14; 115(33):E7776-E7785. Related CAS #: 2183470-12-2 (free base) 2183470-13-3 (acetate)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 10mg

available

Delivery expected until 9/6/2024

Express Delivery: Save 21 days

Compare

Add to wishlist

Recommend by mail