InvivoChem Cat #:V31391CAS #:2271122-53-1Purity >=98%Description: ZK824859 is a novel, potent, orally bioavailable, and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79?nM, 1580?nM and 1330?nM for human uPA, tPA, and plasmin, respectively. ZK824859 showed activity to lower clinical scores when dosed in either acute or chronic mouse EAE mode.
ZK824859 showed activity to lower clinical scores when dosed in either acute or chronic mouse EAE mode.References: Islam I, et al. Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg Med Chem Lett. 2018 Nov 1; 28(20):3372-3375.
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