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cb1-in-1-dbpr211

cb1-in-1-dbpr211

Item no.	V3101-500mg
Manufacturer	InvivoChem LLC
CASRN	1429239-98-4
Amount	500mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3101CAS #:1429239-98-4 Purity >=98% Description: CB1-IN-1 (also known as DBPR211) is a novel, potent, peripherally restricted antagonist of the CB1R (cannabinoid 1 receptor) with Ki values of 0.3 nM and 21 nM for CB1R (EC50 of 3 nM) and CB2R, respectively. CB1-IN-1 has shown significant weight-loss effects and can decrease hepatic steatosis as well as insulin resistance in a diet-induced obese mice model. Therefore, it has great potential to be used in this related metabolic syndrome such as obesity. It also has favorable PK profiles including an extremely low brain to plasma ratio suggesting a low probability to cross BBB. Description: References: J Med Chem. 2013 Dec 27; 56(24):9920-33. References:
Molecular Weight (MW)	751.67
Formula	C33H31Cl2F3N6O3S2
CAS No.	1429239-98-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
Solubility (In vivo)	1-(2, 4-Dichloro-phenyl)-4-[(pyrrolidine-1-sulfonylamino)-methyl]-5-[5-(4-trifluoromethyl-phenylethynyl)-thiophen-2-yl]-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide
Synonyms	DBPR 211; DBPR211; DBPR-211; CB1-IN-1; CB1-IN1; CB1 IN 1; CB1IN 1; CB1IN-1
SMILES Code	O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(C#CC4=CC=C(C(F)(F)F)C=C4)S3)=C1CNS(=O)(N5CCCC5)=O)NN6CCCCC6

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500mg

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