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Description: A-315675, a pyrrolidine-based compound, is a novel and potent anti-infuenza agent. It acts as a neuramidase inhibitor and responds well to resistant strains. A-315675 can inhibit A and B strain influenza virus neuraminidases in enzyme assays and influenza virus replication in cell culture. A-315675 effectively inhibited influenza A N1, N2, and N9 and B strain neuraminidases with inhibitor constant (K(i)) values between 0.024 and 0.31 nM. These values were comparable to or lower than the K(i) values measured for oseltamivir carboxylate (GS4071), zanamivir, and BCX-1812, except for the N1 enzymes that were found to be the most sensitive to BCX-1812.
References: Antimicrob Agents Chemother. 2002 Apr; 46(4):1014-21.
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