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cddo-im

cddo-im

Item no.	V30531-10mg
Manufacturer	InvivoChem LLC
CASRN	443104-02-7
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V30531CAS #:443104-02-7Purity >=98% Description: CDDO-Im (CDDO-imidazolide; TP235; RTA403) is a novel and ptent activator of Nrf2 and PPAR signaling with Kis of 232 and 344 nM for PPARalpha and PPARgamma. It is able to increase Nrf2 protein expression and enhances Nrf2-dependentcytoprotective gene expression. It inhibits cell growth and inducesapoptosis of pancreatic cancer cells in vitro and also reducesacetaminophen-induced liver injury in mice. References: 1. PlaceAE, et al. The novel synthetic triterpenoid, CDDO-imidazolide, inhibitsinflammatory response and tumor growth in vivo. Clin Cancer Res. 2003Jul; 9(7):2798-806. 2. LibyK, et al. The synthetic triterpenoids, CDDO and CDDO-imidazolide, arepotent inducers of heme oxygenase-1 and Nrf2/ARE signaling. Cancer Res.2005 Jun 1; 65(11):4789-98. 3. SoJY, et al. A synthetic triterpenoid CDDO-Im inhibits tumorsphereformation by regulating stem cell signaling pathways in triple-negativebreast cancer. PLoS One. 2014 Sep 17; 9(9):e107616.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10mg

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