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Description: UNC1079, the piperidine analog of UNC1021, is a structurally similar but significantly less potent inhibitor for use as a negative control in cellular studies. It is used as a chemical probe for the methyllysine (Kme) reading function of L3MBTL3, a member of the malignant brain tumor (MBT) family of chromatin-interacting transcriptional repressors. The low anticipated affinity of UNC1079 was confirmed, as it demonstrated an activity versus L3MBTL3 of > 10 uM by AlphaScreen, which is > 1000-fold weaker than UNC1215. UNC1079 also displays weak binding by ITC.
References: Nat Chem Biol. 2013 Mar; 9(3):184-91.
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